Flexor tendon repairin vitro: A comparative histologic study of the rabbit, chicken, dog, and monkey
作者:
Richard H. Gelberman,
Paul R. Manske,
Jerry S. Vande Berg,
Peggy A. Lesker,
Wayne H. Akeson,
期刊:
Journal of Orthopaedic Research
(WILEY Available online 1984)
卷期:
Volume 2,
issue 1
页码: 39-48
ISSN:0736-0266
年代: 1984
DOI:10.1002/jor.1100020107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Flexor tendon;Laceration;Epitenon;Endotenon;Healingin vitro
数据来源: WILEY
摘要:
AbstractFlexor tendon healing in four different animal species was explored in a tissue culture system. Ninety percent transverse lacerations were made in 88 tendon segments obtained from rabbits, chickens, dogs, and monkeys. The tendons were removed from culture and studied by light and electron microscopy at intervals of 3, 6, 9, and 12 weeks. A characteristic sequence of repair including epitenon thickening, cellular differenctiation, cell migration, and phagocytosis was seen in each of the repaired tendons. The endotenon cells of several animal tendons appeared to be synthesizing collagen. There was a consistent difference in the rate of healing between the four species. The rabbit tendons demonstrated nearly complete closure of the repair site by 12 weeks. A lesser response was seen in the chicken, followed by the dog and monkey. The differences in healing rate appeared to be due to the non‐species‐specificin vitroculture media. Thein vitroflexor tendon culture system is particularly useful in studying the tendon repair responses of various species with the contributions of vascularity and synovial cells exclu
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