Stem cell carcinoma of the colon and rectumReport of two cases and review of the literature
作者:
Doris,
Palvio Flemming,
Sørensen Mogens,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1985)
卷期:
Volume 28,
issue 6
页码: 440-445
ISSN:0012-3706
年代: 1985
出版商: OVID
关键词: Colon;Stem cell carcinoma;Multidirectional differentiation;Small‐cell undifferential carcinoma
数据来源: OVID
摘要:
&NA;Two cases of highly malignant tumors, one originating in the sigmoid colon and the other in the rectum, are presented. Both tumors showed light microscopic, electron microscopic, and immunohistochemical evidence of multidirectional differentiation. The tumors were composed mainly of undifferentiated cells, but focally merging into areas with adenocarcinomatous and squamous differentiation. Ultrastructurally and histochemically, a predominant endocrine differentiation was present in the undifferentiated areas of the tumors. These two cases lend further support to the recent concept of a pluripotential stem cell in the mucosa of the gastrointestinal tract capable of differentiation in several directions.
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