Clomiphene Citrate Alters Vaginal Surface Morphology in Cycling Rats
作者:
V. Terry,
Ch.R. Murphy,
C.D. Shorey,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 3
页码: 212-215
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147368
出版商: S. Karger AG
关键词: Vagina;Vaginal epithelium;Clomiphene citrate;Scanning electron microscopy
数据来源: Karger
摘要:
Cycling virgin female rats were treated with clomiphene citrate (CC) during dioestrus of the reproductive cycle. Animals were sacrificed 2 days after the initial injection and their vaginal tissue was examined by scanning electron microscopy. Animals treated with one dose of CC had an epithelium consistent with a prolonged dioestrus. Treatment with CC for 2 days induced changes in the epithelium that had no resemblance to any normal hormonally controlled event in the vagina. It was found that CC had effects consistent with progesterone alone as well as effects unique to this superovulatory drug.
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