Consider an unstable uncertain plant controlled by an elementNp, which saturates when its input |x| ≥M. The system can be stabilized by means of feedback, which, however, is absent duringNpsaturation. If the saturation interval is long enough, it is impossible to recover system stability viaNp. This paper presents a synthesis technique for ensuring thatNpdoes not saturate despite very large command inputs. The basic idea is to prevent |x|>M, via an added saturating elementNwith saturation levelm, which in turn is determined by |x|. A systematic, quantitative design technique is presented for unstable plants with large uncertainty, to achieve (a) desired performance tolerances over the linear range (small command inputs) and (b)acceptable but unavoidably slower response for large command inputs. Both (a) and (b) are achieved over the specified extent of plant uncertainty. The design technique makes use of several previously developed quantitative synthesis theories for minimum- and non-minimum-phase uncertain plants in linear operation, and for uncertain minimum-phase stable plants subject to saturation.