Do Carotid Chemoreceptors Inhibit the Hyperventilatory Response to Heavy Exercise?
作者:
Jerome A. Dempsey,
Curtis A. Smith,
期刊:
Canadian Journal of Applied Physiology
(NRC Available online 1994)
卷期:
Volume 19,
issue 3
页码: 350-359
ISSN:1066-7814
年代: 1994
DOI:10.1139/h94-028
出版商: NRC Research Press
关键词: hypocapnic inhibition;medullary chemoreceptors;locomotor-linked stimuli;feed-forward
数据来源: NRC
摘要:
In this paper two types of evidence are presented which question the commonly presumed role of carotid chemoreceptor stimulation as the primary mediator of the hyperventilatory response to heavy exercise. First, carotid-body denervation in ponies increases their hyperventilatory response to heavy exercise. Second, the awake dog and the goat at rest show an immediate and substantial depression of tidal volume and of ventilation when their isolated carotid chemoreceptors are made hypocapnic. Accordingly, it is proposed that during heavy exercise the carotid chemoreceptors are inhibitory to respiratory motor output and that the cause of the hyperventilatory response originates from extrachemoreceptor, locomotor-linked, feed-forward stimuli.Key words: hypocapnic inhibition, medullary chemoreceptors, locomotor-linked stimuli, feed-forward
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