Bile concentration is a key factor for nucleation of cholesterol crystals and cholesterol saturation index in gallbladder bile of gallstone patients
作者:
Karel J. Van Erpecum,
Gerard P. Berge Van Henegouwen,
Bregt Stoelwinder,
Yvonne M. G. Schmidt,
Frans L. H. Willekens,
期刊:
Hepatology
(WILEY Available online 1990)
卷期:
Volume 11,
issue 1
页码: 1-6
ISSN:0270-9139
年代: 1990
DOI:10.1002/hep.1840110102
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractWe investigated whether bile concentration influenced cholesterol saturation index or nucleation time of cholesterol monohydrate crystals in a large number of gallbladder bile samples. Pigment stone patients never had cholesterol crystals in their fresh biles, and nucleation time was always longer than 20 days. Of the cholesterol stone patients 79% had cholesterol crystals in their fresh biles. Long nucleation times were generally found in cholesterol stone patients with dilute biles despite a high cholesterol saturation index. Nucleation time was usually short if bile was well concentrated depite a relatively low saturation index. Serialin vitrodilution of concentrated biles from cholesterol gallstone patients resulted in progressively prolonged nucleation times. Patients with solitary cholesterol stones had longer nucleation times than patients with multiple cholesterol stones. This study indicates that bile concentration is an important factor for nucleation time and cholesterol saturation index. Moreover, solitary and multiple cholesterol stones may have a different pathogenesis. (HEPATOLOGY 1990; 11: 1–6
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