Cleavage of rhamnose from ristocetin A removes its ability to induce platelet aggregation
作者:
B Bardsley,
D H Williams,
T P Baglin,
期刊:
Blood Coagulation and Fibrinolysis
(OVID Available online 1998)
卷期:
Volume 9,
issue 3
页码: 241-244
ISSN:0957-5235
年代: 1998
出版商: OVID
关键词: naringinase;platelet aggregation;ristocetin
数据来源: OVID
摘要:
Ristocetin A is used clinically as a tool for the measurement of von Willebrand protein due to its ability to induce the aggregation of platelets in plasma being proportional to the concentration of von Willebrand protein. The enzymatically induced cleavage ofα- l-rhamnose from the tetrasaccharide of ristocetin A removes this ability to induce platelet aggregation in plasma, providing a possible insight into the structural basis for this effect.
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