RISK FACTORS FOR HALOTHANE HEPATITIS
作者:
MichaelJ. Cousins,
JohnL. Plummer,
Pauline de la M. Hallt,
期刊:
Australian and New Zealand Journal of Surgery
(WILEY Available online 1989)
卷期:
Volume 59,
issue 1
页码: 5-14
ISSN:0004-8682
年代: 1989
DOI:10.1111/j.1445-2197.1989.tb01457.x
出版商: Blackwell Publishing Ltd
关键词: anaesthetic complications;halothane hepatitis;halothane metabolism;pre‐operative complications.
数据来源: WILEY
摘要:
Helothane hepatitis is a rare but sometimes fatal complication of halothane anaesthesia. Examination of case reports has pointed to a number of risk factors. Studies in animals and humans in the laboratory have provided evidence of a complex multifactorial basis for halothane hepatotoxicity, with the following factors playing a part: genetic predisposition; metabolism of halothane; repeated halothane anaesthetics; female sex; age of patient; intrahepatic hypoxia; and enzyme induction. Immunologic changes can be detected in a high percentage of cases of halothane hepatitis; however, studies establishing a cause‐effect relationship are not available to determine if these changes cause, or result from, hepatic damag
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