Determination of 17-Hydroxycorticosteroids in Dialysate Solution as a Measure of Adrenocortical Function in Hemodialysis Patients
作者:
Yukimasa Kohda,
Ryoji Hiramatsu,
Kuniharu Kuwahara,
Tatsuo Sato,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 1
页码: 71-75
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187769
出版商: S. Karger AG
关键词: 17-Hydroxycorticosteroid;Hemodialysis;Adrenocortical function;Renal failure
数据来源: Karger
摘要:
Dialysate contents of 17-hydroxycorticosteroids (17-OHCS) in hemodialysis patients were studied as a potential measure of adrenocortical function. Dialysate 17-OHCS contents after a 2-day interval of hemodialysis in 15 hemodialysis patients were determined. Dialysate 17-OHCS increased after intravenous injection of cortisol the evening prior to hemodialysis (n = 4). Dialysate 17-OHCS content was suppressed, as was plasma cortisol, after a standard dexamethasone (Dex) suppression test (n = 1). Their plasma cortisol was suppressible or nonsuppressible by an overnight Dex suppression test, as reported previously. However, basal dialysate 17-OHCS contents were not different between them, indicating that the nonsuppressible patients with overnight Dex seem not to have hypercortisolism. We conclude that determination of dialysate 17-OHCS seems a useful noninvasive technique for the evaluation of adrenocortical function in hemodialysis patients.
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