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Human MHC Class III Genes, Bf and C4. Polymorphism, Complotypes and Association with MH...
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Human MHC Class III Genes, Bf and C4. Polymorphism, Complotypes and Association with MHC Class I Genes in the Finnish Population
作者:
J. Partanen,
S. Koskimies,
期刊:
Human Heredity
(Karger Available online 1986)
卷期:
Volume 36,
issue 5
页码: 269-275
ISSN:0001-5652
年代: 1986
DOI:10.1159/000153642
出版商: S. Karger AG
关键词: HLA haplotypes;Finnish population;MHC class III;Genetic polymorphism
数据来源: Karger
摘要:
Electrophoretically detected genetic polymorphism of human MHC class III genes, factor B (Bf) and complement C4A and C4B, was studied in the Finnish population. Bf alleles were determined in a panel of sera from 70 unrelated individuals. The common Bf alleles, Bf*S and Bf*F, had frequencies of 73% and 26%, respectively. Only in 1 individual was another allele, Bf*Fl, detected. The frequencies of the C4A and C4B alleles were based on studies of 254 unrelated individuals. In this panel, five different alleles were detected at the C4A locus and four at the C4B locus. At both loci an allele without a gene product, i.e. a ‘null’ allele, was observed with high frequency, 11 % for C4A ‘null’ and 17% for C4B ‘null’. The association of complotypes to HLA haplotypes was analyzed in 70 chromosomes. The most common combination, defined by class I and class III alleles, was HLA-B7-S31 (13%), followed by HLA-B35-F20 (8.4%) and HLA-B8-S03 (7.1%). Some HLA-B specificities, for example B15, B27 and B40, were associated with a variety of complotypes. The importance of complotyping in HLA genetics i
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