Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin
作者:
L. DOBROWOLSKI,
K. ENDLICH,
J. SADOWSKI,
M. STEINHAUSEN,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1997)
卷期:
Volume 159,
issue 1
页码: 7-13
ISSN:0001-6772
年代: 1997
DOI:10.1046/j.1365-201X.1997.583331000.x
出版商: Blackwell Science
关键词: endothelin receptor inhibitor;PD 145065;renal circulation;urodilatin
数据来源: WILEY
摘要:
Role of endogenous endothelins (ET) in the control of cardiovascular system and renal function, and ET interaction with urodilatin (URO) were studied in anaesthetized rats. Activity of ET was blocked using PD 145065 (5 mg kg‐1body wt i.v.), a non‐selective antagonist of ETAand ETBreceptors. PD 145065 decreased mean arterial blood pressure (MBP) from 114±4 to 109±4 mmHg and the renal blood flow (RBF) from 6.6±0.3 to 5.8±0.4 mL min‐1(P<0.02) and increased renal vascular resistance (RVR) from 17.7±1.2 to 20.1±2.1 mmHg min mL‐1. Heart rate (HR) and renal function were not affected. URO was infused i.v. at 0.1 nmol min‐1 kg‐1body wt without or with previous ET receptor blockade. After pre‐treatment with PD 145065, infusion of URO decreased MBP more than did URO alone: 15±3% vs. 7±2% (P<0.05). RVR and HR did not change after URO alone but decreased with URO given to PD 145065 treated rats (19±5% and 14±3%, respectively,P<0.01). It is concluded that in anaesthetized surgically prepared rats endogenous ET can cause renal vasodilation, in contrast to constriction of systemic vasculature. Enhancement by ET blockade of vascular systemic and renal effects of URO supports ET interaction with natriuretic peptides in the control of cardiovas
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