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Suppression of the acute inflammatory response of porcine alveolar‐ and liver macrophages

 

作者: C.A. Izeboud,   M. Monshouwer,   R.F. Witkamp,   A.S.J.P.A.M. van Miert,  

 

期刊: Veterinary Quarterly  （Taylor Available online 2000）
卷期: Volume 22, issue 1  

页码: 26-30

 

ISSN:0165-2176

 

年代: 2000

 

DOI:10.1080/01652176.2000.9695019

 

出版商: Taylor & Francis Group

 

关键词: macrophages;porcine;inflammation;LPS;TNF‐α

 

数据来源: Taylor

 

摘要:

During infection and inflammation drug disposition and hepatic metabolism are markedly affected in mammals. Pro‐inflammatory mediators play an important role in the suppression of (cytochrome‐P450‐mediated) drug metabolism. Inflammatory mediators like cytokines, nitric oxide (NO), reactive oxygen species (ROS) and eicosanoids are released by activated macrophages from various sources, including liver and lung.

 

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