Determination of Meloxicam in Tablet Formulations by Ultraviolet Spectrophotometry and High-Performance Liquid Chromatography
作者:
J. Joseph-Charles,
M. Bertucat,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 10
页码: 2051-2059
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542951
出版商: Taylor & Francis Group
关键词: Meloxicam determination;UV spectrophotometry;High-performance liquid chromatography;Tablet formulations
数据来源: Taylor
摘要:
Assay procedures based on UV spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the determination of meloxicam in tablet formulations. The HPLC method used a reversed-phase C18 column with 0.05M Tris acetic acid buffer - tetrabutylammonium reagent–acetonitrile as eluent, and UV detection at 360nm with isoxicam as the internal standard. The UV method was based on measuring an acidic solution of the drug at 341nm. A comparison was established in terms of linearity, sensitivity, precision, and accuracy. Both methods were simple and rapid. HPLC was more precise and more accurate, the UV technique was slightly faster.
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