Stimulation of feeding in lean but not in obese Zucker rats by a selective neuropeptide Y Y5 receptor agonist
作者:
Philipp Wyss,
Nigel Levens,
Alain Stricker-Krongrad,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2675-2677
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Agonist;Eating disorders;Food intake;Hyperphagia;Obesity;Zucker rats
数据来源: OVID
摘要:
OBESE Zucker rats are characterized by a reduced hypothalamic NPY receptor density. We tested the effects of intracerebroventricular injections of human NPY (hNPY) and [D-Trp32]NPY, a weak but selective NPY Y5 receptor agonist, on food intake in lean and obese Zucker rats. The effect of a maximal dose of hNPY (10 mg) on feeding was more pronounced in lean than in obese rats. [D-Trp32]NPY (10 μg) stimulated feeding in lean but not in obese Zucker rats. It did not affect the feeding response to hNPY, excluding the activation of an inhibitory receptor. These results are in favor of a down-regulation of the NPY 'feeding' receptor in the obese rat, which is suggested to be the Y5 subtype.
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