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Lack of Neurotoxic Effect of Diethylpropion in Crack‐Cocaine Abusers

 

作者: Christine Ollo,   Tanya Alim,   Richard Rosse,   Teresa Lindquist,   Thomas Green,   Tama Gillis,   Judy Ricci,   Mushtari Khan,   Stephen Deutsch,  

 

期刊: Clinical Neuropharmacology  (OVID Available online 1996)
卷期: Volume 19, issue 1  

页码: 52-58

 

ISSN:0362-5664

 

年代: 1996

 

出版商: OVID

 

关键词: Crack‐cocaine abuse;Neuropsychology;Cognition;Stimulants;Diethylpropion.

 

数据来源: OVID

 

摘要:

Summary:Dopamine agonists have been used with some success in treating cocaine addiction. However, both cocaine and psychostimulants have been reported to produce neurotoxic effects. We evaluated the effect of the stimulant diethylpropion on cognitive performance in a double‐blind, placebocontrolled trial. Forty‐six abstinent crack‐cocaine users received either placebo, 25‐mg, 50‐mg, or 75‐mg doses of diethylpropion. Patients were tested at baseline and again after 9‐14 days of medication. There were no differences between placebo and medication groups on any test, indicating that, within the time frame studied, diethylpropion does not produce neurotoxic effects that can be detected with standardized neuropsychological tests.

 

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