AbstractTo develop new cytotoxins, which could find use as anti‐cancer agents, polyamine conjugates were synthesized containing spermine and an anthracene or acridine unit. Spermine is known to groove‐bind to DNA; anthracene and acridine are known to intercalate. It was hoped that these polyamine‐polyaromatic conjugates would use both modes of binding.Studies of growth inhibition of B16 murine melanoma cells showed the conjuates to be more effective than either spermine, anthracene‐9‐carboxylic acid or acridine‐9‐carboxylic acid, and of the conjugates, the acridine derivative showed grea