Hepatitis A booster vaccine in children after infant immunization
作者:
GÜLER,
KANRA SONGÜL,
YALÇIN ATES,
KARA ELIF,
ÖZMERT KADRIYE,
期刊:
The Pediatric Infectious Disease Journal
(OVID Available online 2002)
卷期:
Volume 21,
issue 8
页码: 727-730
ISSN:0891-3668
年代: 2002
出版商: OVID
关键词: Hepatitis A;revaccination;immunogenicity;infant;children
数据来源: OVID
摘要:
Background.Hepatitis A vaccine provides long term protection against hepatitis A infection in adults and children older than 2 years of age. Few data are available regarding children younger than 2 years of age.Methods.Children who were vaccinated in infancy with hepatitis A vaccine were revaccinated at 4 years of age, and antibody titers were followed. Forty-four subjects who had been vaccinated with hepatitis A vaccine [Havrix, 360 enzyme-linked immunosorbent assay units (EU)] at the age of 2, 4 and 6 months were revaccinated with 720 EU of inactivated hepatitis A vaccine (Havrix) at 4 years of age.Results.Geometric mean titer (GMT) of 44 evaluable cases was 41 mIU/ml and 34 children (77.3%) were seropositive before the booster dose. Postvaccination blood samples were obtained from 37 cases. One month after booster dose GMT increased to 2884 mIU/ml, and all subjects were seropositive. Ten seronegative cases also seroconverted. The GMT of the seropositive cases showed anamnestic response after the booster dose (57 mIU/ml before booster dose, 5623 mIU/ml after the booster). No serious adverse event was seen after the booster dose.Conclusion.We conclude that childhood hepatitis A virus revaccination after infant immunization is highly immunogenic and safe.
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