Doxylamine Overdose as a Potential Cause of Rhabdomyolysis
作者:
Biana Leybishkis,
Panayotis Fasseas,
Kathleen Ryan,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 2001)
卷期:
Volume 322,
issue 1
页码: 48-49
ISSN:0002-9629
年代: 2001
出版商: OVID
关键词: Doxylamine;rhabdomyolysis;overdose
数据来源: OVID
摘要:
Doxylamine succinate, an over-the-counter antihistamine, is commonly used as a nighttime sleep aid in the short-term management of insomnia. It is also used in combination with antitussive and decongestant agents for the temporary relief of common cold symptoms. Doxylamine is frequently involved in accidental and intentional overdoses. Rhabdomyolysis and secondary acute renal failure are rare but potentially serious complications, making early recognition and treatment essential. With the large number of nonprescription antihistamines and sleep aids available to the general public, it is important to keep in mind that overdose is a potential problem. The complications associated with overdose of these medications are just as life threatening as those associated with prescription drugs. A high index of suspicion and evaluation of rhabdomyolysis is warranted in antihistamine toxicity. We report an observation of severe rhabdomyolysis associated with doxylamine overdose.
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