In vitro influence of molybdenum on benzo[a]pyrene metabolism in hepatic and pulmonary rat microsomes
作者:
Guy Bompart,
Philippe Puig,
Bernard Pipy,
Maryse Béraud,
Marie‐Claude Souqual,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 26,
issue 4
页码: 459-468
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531269
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Our study presents the in vitro molybdenum influence on benzo[a]pyrene (BaP) micro‐somal metabolism. Addition of various concentrations of different molybdenum salts [MoS2, MoCl5, (NH4)6Mo7O244H2O] to liver and lung microsomal fractions of rats previously treated with 3‐methylcholanthrene produces a decrease in the different BaP metabolites assessed by high‐performance liquid chromatography (HPLC) analysis. This inhibition varies, depending on the considered metabolite and in relation to both the molybdenum level and the origin of the microsomal suspension. The minimum effective concentration is 0.26 and 0.52 mM Mo from liver and lung, respectively. The inhibitory potencies of the +5 (chloride) and +6 (ammonium heptamolybdate) molybdenum compounds are comparable; that of the sulfide is lower.
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