Treatment of Myelodysplastic Syndromes with Orally Administered l-β-Z)-Arabinofuranosylcytosine-5’-Stearylphosphate
作者:
Ryuzo Ohno,
Noriyuki Tatsumi,
Masami Hirano,
Kuniyuki Imai,
Hideaki Mizoguchi,
Tohru Nakamura,
Masaaki Kosaka,
Kiyoshi Takatsuki,
Toshihiko Yamaya,
Keisuke Toyama,
Takashi Yoshida,
Tohru Masaoka,
Shuji Hashimoto,
Toshiteru Ohshima,
Ikuro Kimura,
Kazumasa Yamada,
Kiyoji Kimura,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 6
页码: 451-455
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226979
出版商: S. Karger AG
关键词: l-β-D-Arabinofuranosylcytosine-5’-stearylphosphate;Fosteabine;YNK-01;Clinical study;Phase II study;Myelodysplastic syndromes;Leukemia;Cytarabine
数据来源: Karger
摘要:
l-P-Z)-Arabinofuranosylcytosine-5’-stearylphosphate (fosteabine) was administered orally to patients with myelodysplastic syndromes (MDS); refractory anemia with excess of blasts (RAEB), RAEB in transformation, acute leukemia derived from RAEB and chronic myelomonocytic leukemia, in an early phase II study in a multi-institutional study. Among 62 evaluable patients, 2 patients achieved a complete remission, 6 a good response and 8 partial response by daily oral administration of 100–200 mg of fosteabine. The overall response rate was 25.8%. The response rates were almost the same among the four subtypes of MDS. Responses were reached 2–23 weeks (median, 8 weeks) after the start of therapy and continued for 3–50 weeks (median, 10 weeks). Major side effects were myelosuppression and gastrointestinal toxicities. In spite of the disadvantages, such as unpredictable absorption, this newly developed orally administrable cytarabine analogue will be a useful drug in the treatment
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