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Synthesis of 1,6-Anhydro-2,3-di-O-farnesyl-5-O-([{phosphonomethyl}phosphinyl]methyl)-α-d-galactofuranose: A Zaragozic Acid-Presqualene Pyrophosphate Hybrid

 

作者: A.R.P.M. Valentijn,   H.J.G. Broxterman,   G.A. van der Marel,   L.H. Cohen,   J.H. van Boom,  

 

期刊: Journal of Carbohydrate Chemistry  （Taylor Available online 1995）
卷期: Volume 14, issue 6  

页码: 737-749

 

ISSN:0732-8303

 

年代: 1995

 

DOI:10.1080/07328309508005373

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

A multi-step synthesis of a new potential inhibitor (i.e., compound2) of squalene synthase is described, starting from D-galactose. The title compound is a hybrid of presqualene pyrophopshate and the recently discovered zaragozic acids, which are picomolar competitive inhibitors of the enzyme squalene synthase.

 

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