SIMULATION AND DESIGN 0f HEATING PROFILSS IN HEATCONTROLLED FREEZE-DRYING OF PHARMACKUTICALS IN VIALS BY THE APPLICATION OF A SUBLIMATION SEMISPHERICAL MODEL.
作者:
J.I. Loubiuna,
C. De Elvira,
M.C. Villaran,
J. Izcara,
期刊:
Drying Technology
(Taylor Available online 1993)
卷期:
Volume 11,
issue 3
页码: 471-487
ISSN:0737-3937
年代: 1993
DOI:10.1080/07373939308916839
出版商: Taylor & Francis Group
关键词: Freeze-drying;modelling;heating strategies;operating conditions
数据来源: Taylor
摘要:
The freeze-drying of a certain pharmaceutical contained in vials in industrial like conditions has been described by a sublimation model under analogous semispherical configuration. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperacure evolutions. The model offers interesting perspectives to obtain orientative simulated results in heating strategies analysis in order to reduce drying time.
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