Presence and role of cytokines and growth factors in invertebrates
作者:
Enzo Ottaviani,
Antonella Franchini,
Dimitris Kletsas,
Claudio Franceschi,
期刊:
Italian Journal of Zoology
(Taylor Available online 1996)
卷期:
Volume 63,
issue 4
页码: 317-323
ISSN:1125-0003
年代: 1996
DOI:10.1080/11250009609356152
出版商: Taylor & Francis Group
关键词: Cytokines;Growth factors;Invertebrates
数据来源: Taylor
摘要:
Available data from our and other laboratories on the presence and biological functions of cytokine‐ and growth factor‐like molecules in invertebrates are reviewed. It appears that IL‐1α‐, IL‐1ß‐, IL‐2‐, IL‐6‐, TNF‐α‐like molecules and haemokinin are present in several cell types from molluscs, insects, annelids, echinodems and tunicates. In most cases, these molecules are present in cells with phagocytic activity and they modulate cell motility. PDGF‐, TGF‐ß‐, EGF‐ and NGF‐like molecules, growth promoting factors and the hemolymph trophic factor are present in several cell types from molluscs, insects and annelids. These molecules are probably involved in the control of cell proliferation. Both cytokines and growth factors appear to be highly ancestral and biologically very important molecules, as evident from their continuous presence from invertebrates to vertebrates. It also appears that cytokines are functionally conserved molecules, which during evolution have also maintained their pleiotropicity, redundancy in mode of action and the promiscuity of their receptors.
点击下载:
PDF (715KB)
返 回