Functional spectroscopy of brain activation following a single light pulse: Examinations of the mechanism of the fast initial response
作者:
J. Hennig,
C. Janz,
O. Speck,
T. Ernst,
期刊:
International Journal of Imaging Systems and Technology
(WILEY Available online 1995)
卷期:
Volume 6,
issue 2‐3
页码: 203-208
ISSN:0899-9457
年代: 1995
DOI:10.1002/ima.1850060210
出版商: John Wiley&Sons, Inc.
数据来源: WILEY
摘要:
AbstractLocalized proton spectroscopy using the PRESS sequence was performed to measure the free induction decay of the water signal in a 2 × 2 × 2 = ml voxel located in the visual cortex after a short light pulse. The experiment was run continuously with a repetition time of 400 ms; the onset of the light pulse was triggered by the spectrometer. The FIDs were measured as a function of the echo time (TE) and the length of the stimulus (TS). The time course showed three different phases: An initial response was observed 400 ms after the onset of the stimulus, which was demonstrated to be mainly a change in the apparent spin density and/or T1with a minor contribution of T2*. No significant change in T2could be measured. Changes in the ionic cell environment and/or the subsequent increase in cell size upon stimulation are discussed as a potential mechanism for the observed signal respons
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