The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (Callithrix jacchus)
作者:
C. W. Davy,
M. Fulleylove,
J. G. Edmunds,
D. A. Eichler,
B. Rushton,
R. J. Tudor,
J. M. Walker,
期刊:
Journal of Applied Toxicology
(WILEY Available online 1989)
卷期:
Volume 9,
issue 1
页码: 33-37
ISSN:0260-437X
年代: 1989
DOI:10.1002/jat.2550090107
出版商: John Wiley&Sons, Ltd.
关键词: carbon tetrachloride;marmoset;isocitrate dehydrogenase;myotoxicity;agarose electraphoresis;callithrix jacchus
数据来源: WILEY
摘要:
AbstractMarmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. Although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (ICDH), only the isoenzyme analysis of ICDH can differentiate definitely between liver and muscle damage. Only very severe muscle damage can increase the plasma concentration of this enzyme but, in this case, the elevation of plasma creatinine kinase levels helps differentiation. It is recommended that the elevation of ICDH is the most specific indicator of hepatic damage in the marmoset.
点击下载:
PDF
(509KB)
返 回