Increased Serum Erythropoietin Level during Azathioprine Treatment in Renal Transplant Recipients
作者:
Jens D. Jensen,
Hans E. Hansen,
Erling B. Pedersen,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 3
页码: 297-301
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187982
出版商: S. Karger AG
关键词: Erythropoietin;Glomerular filtration rate;Hematocrit;Renal transplantation;Cyclosporine;Azathioprine
数据来源: Karger
摘要:
One hundred and six renal transplant patients were studied. During the first 12 months after renal transplantation all patients were treated with cyclosporine (Cy) and prednisone. At 12 months after transplantation the patients were randomly allocated to either conventional treatment with azathioprine (Az) and prednisone (group Az) or to continued treatment with Cy and prednisone (group Cy). Serum erythropoietin (s-EPO), glomerular filtration rate (GFR) and hematocrit (Hct) were measured at 12,18 and 24 months after transplantation. s-EPO rose in the group Az from 19 U/l (mean) at 12 months to 28 U/l (p < 0.01) at 18 months and remained elevated at 24 months at 29 U/l compared with baseline level and with healthy subjects without anemia 18 U/l (p < 0.01). There was no significant change in s-EPO in group Cy during the study. The Hct in the two groups was not significantly different. GFR was the same in the two groups at 12 months and after 24 months. In conclusion, a switch from Cy to Az 1 year after renal transplantation results in a sustained rise in s-EPO which may in part represent a compensatory phenomenon to bone marrow suppression.
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