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Anticonvulsant activity of a new 1,4‐benzodiazepine in rodents and the baboonPapio papio

 

作者: David C. Piper,   B. S. Meldrum,   C. R. Gardner,  

 

期刊: Drug Development Research  （WILEY Available online 1981）
卷期: Volume 1, issue 1  

页码: 77-82

 

ISSN:0272-4391

 

年代: 1981

 

DOI:10.1002/ddr.430010110

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: anticonvulsant;benzodiazepines;rodents;baboon

 

数据来源: WILEY

 

摘要:

AbstractRU 31124, a new anticonvulsant 1,4‐benzodiazepine was compared with clonazepam in a series of tests in rats and mice. It demonstrated greater anticonvulsant potency whilst having equivalent sedative properties to clonazepam. This profile of activity was confirmed in the photosensitive baboon,Papio papio, in which RU 31124 provided long‐lasting protection against convulsions at doses having little or no sedative side effe

 

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