Recent results are reviewed which demonstrate that finding the earliest quasars and galaxies in the universe will require infrared spectroscopy between 1 and 10 microns. Technical limitations on such observations from the Moon are summarized, which depend primarily on background emission from the telescope and the zodiacal dust. Detection of the most distant star forming galaxies will require exceptional background stability for which angular resolution better than about 1 arcsecond is not critical, so a large filled‐aperture telescope of nominal image quality will be adequate. For quasars, detection improves with increasing angular resolution, so the best possible image quality is important, particularly to obtain diffraction limited performance shortward of 3 microns. A summary is given of what could be seen as a function of available telescope aperture.