Pharmacokinetics of Carboplatin in a Patient Suffering from Advanced Ovarian Carcinoma with Hemodialysis-Dependent Renal Insufficiency
作者:
Etienne Chatelut,
Lionel Rostaing,
Virginie Gualano,
Thierry Vissac,
Marcel De Forni,
Hughes Ton-That,
Jean Michel Suc,
Georges Houin,
Pierre Canal,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 2
页码: 157-161
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187794
出版商: S. Karger AG
关键词: Carboplatin;Hemodialysis;Pharmacokinetics
数据来源: Karger
摘要:
Pharmacokinetics of carboplatin were determined in a patient suffering from advanced ovarian cancer with total hemodialysis-dependent chronic renal failure undergoing 3 consecutive cycles of chemotherapy. Dosage was adjusted to reach active AUC (area under the plasma concentration versus time curve) of ultrafïlterable carboplatin. A hemodialysis, performed 24 h after administration, results in a decrease of 20% of ultrafilterable carboplatin AUC. The relative dialysis efficacy of ultrafilterable carboplatin was great: 84 ± 3%. The chemotherapy regimen consisted of carboplatin-cyclophosphamide combination for 6 cycles every 4 weeks. After treatment completion, the patient showed a complete response and remains disease free 16 months after the end of the treatment. Carboplatin-based chemotherapy can be given to patients undergoing chronic hemodialysis without life-threatening toxicity with a dialysis performed 24 h after the administration and with a dose adjustment of carboplatin to reach a AUC of 6 mg/ml min for untreated patients. In these conditions, response in platinum-sensitive tumors can be obtaine
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