This study investigated whether enhanced metabolic responsiveness to p‐adrenergic stimulation might explain the liability of the stress‐sensitive pig to develop an acidosis during stressful situations. Blood lactate, pH,Pco2and heart rate response to an intravenous infusion of isoprenaline were examined in three lines of pentobarbitone anaesthetized, atropinized pigs. The lines were Pietrain × Hampshire which had been selected over eight generations for a positive reaction to the halothane test (stress‐sensitive); Pietrain x Hampshire which had been selected over eight generations for no reaction to the halothane test (stress‐resistant) and British Landrace which had been selected over four generations for a positive halothane reaction (stress‐sensitive). The metabolic responses to isoprenaline were greater in the stress‐sensitive Pietrain × Hampshire line than the stress‐resistant line. The stress‐sensitive Landrace pigs, however, had smaller changes in pH andPco2in response to isoprenaline than the stress‐resistant Pietrain × Hampshire pigs. This inconsistent trend across the three lines led to the conclusion that enhanced P‐adrenergic responsiveness was not the likely cause