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Hyperbaric oxygenation in severe perineal Crohn's disease

 

作者: Jean‐Frédéric Colombel,   Daniel Mathieu,   Jean‐Michel Bouault,   Xavier Lesage,   Patrick Zavadil,   Pierre Quandalle,   Antoine Cortot,  

 

期刊: Diseases of the Colon & Rectum  (OVID Available online 1995)
卷期: Volume 38, issue 6  

页码: 609-614

 

ISSN:0012-3706

 

年代: 1995

 

出版商: OVID

 

关键词: Crohn's disease;Perineal;Hyperbaric oxygenation

 

数据来源: OVID

 

摘要:

PURPOSE:Perineal involvement in Crohn's disease is a common and distressing condition, often refractory to medical or surgical treatments. Recent reports suggest the efficacy of hyperbaric oxygenation (HBO) in the healing of perineal lesions. We evaluated HBO in severe patients with perineal Crohn's disease.METHODS:Ten consecutive patients (8 women, 2 men; mean age, 30 years) were studied. There were four superficial fissures, four cavitating ulcers, six low or superficial fistulas, two high fistulas, and one irreversible anal stenosis. All patients had received one or more medical treatments without healing the perineal lesions, and all had had previous surgery for perineal lesions.RESULTS:Two patients discontinued HBO after a few sessions and did not complete treatment. Eight patients completed at least 30 HBO sessions and were evaluable. At the end of the procedure, six of eight patients treated were healed, three completely and three partially. All patients who healed completely received HBO as an additional treatment to local perineal surgery.CONCLUSION:HBO might be useful as a last resort treatment of chronic perineal Crohn's disease, resistant to other treatments or as a complement to surgery.

 

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