1,4‐Benzodiazepines. Chemistry and Some Aspects of the Structure‐Activity Relationship
作者:
Leo H. Sternbach,
期刊:
Angewandte Chemie International Edition in English
(WILEY Available online 1971)
卷期:
Volume 10,
issue 1
页码: 34-43
ISSN:0570-0833
年代: 1971
DOI:10.1002/anie.197100341
出版商: Hüthig&Wepf Verlag
关键词: Benzodiazepines;Structure–activity relationships;Tranquilizers
数据来源: WILEY
摘要:
AbstractNumerous clinically used compounds having favorable tranquilizing and toxic properties possess the 1,4‐benzodiazepine skeleton. This group of active substances is readily accessible, e.g. by ring enlargement of quinazoline derivatives, by ring contraction of benzoxadiazocines, and by synthesis from aminobenzophenones, constructing the seven‐membered ring in many cases in one step. The relationships between type and position of substituents and the pharmacological properties are illustrated using 1,3‐dihydro‐5‐phenyl‐1,4‐benzodiazepin‐2
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