Citropten and Bergapten Suction Blister Fluid Concentrations after Solar Product Application in Man
作者:
P. Treffel,
S. Makki,
B. Faivre,
P. Humbert,
D. Blanc,
P. Agache,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1991)
卷期:
Volume 4,
issue 2
页码: 100-108
ISSN:1660-5527
年代: 1991
DOI:10.1159/000210931
出版商: S. Karger AG
关键词: Percutaneous absorption;HPLC;Citropten;Bergapten;Suction blister
数据来源: Karger
摘要:
Citropten (5,7-dimethoxycoumarin) and bergapten (5-methoxypsoralen) are present in bergamot oil which is used as a cosmetic tanning product. The aim of this study was to quantify, using HPLC, the amount of citropten and bergapten in the skin after the application of suntan products (emulsion and oil formulations). A suction blister technique, performed on the volar aspect of the forearm, permitted the collection of these two molecules. The blister fluid concentrations were 37 and 51 ng/ml (emulsion) and 26 and 23 ng/ml (oil), respectively, for citropten and bergapten. Our results show that the suction blister technique could be used for comparing transepidermal penetration of several compounds in vivo in man.
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