Platelet Dysfunction in Nutritional Vitamin B12Deficiency
作者:
GhoshK.,
KrishnaV.,
MohantyD.,
期刊:
Platelets
(Taylor Available online 1991)
卷期:
Volume 2,
issue 3
页码: 153-156
ISSN:0953-7104
年代: 1991
DOI:10.3109/09537109109006026
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Platelet aggregation to four different agonists was measured in platelet-rich plasma from 17 patients with nutritional vitamin B12deficiency; 10 of these patients were also iron deficient. Impaired aggregation to ADP, collagen, epinephrine and ristocetin was found for 4, 8, 10 and 6 patients, respectively. Bleeding manifestations were seen in 5 patients, one belonging to the vitamin B12deficiency group and 4 to the combined deficiency group. Three of these 5 patients had normal platelet aggregation. These results show that impaired platelet aggregation is common in nutritional vitamin B12deficiency but that this impairment does not reliably correlate with a clinical bleeding tendency.
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