Renal responses to atrial natriuretic factor during converting enzyme inhibition
作者:
Sue-Lin Wang,
Joseph P. Gilmore,
期刊:
Canadian Journal of Physiology and Pharmacology
(NRC Available online 1985)
卷期:
Volume 63,
issue 3
页码: 220-223
ISSN:0008-4212
年代: 1985
DOI:10.1139/y85-041
出版商: NRC Research Press
数据来源: NRC
摘要:
The effect of converting enzyme inhibitor (CEI) on the renal response to atrial natriuretic factor (ANF) was determined in the rat. In the absence of CEI, ANF produced rapid and significant increases in sodium, potassium, calcium, and urine excretions while blood pressure declined transiently. In the presence of CEI, ANF enhanced the excretion of sodium and potassium but not of calcium and urine. The activity of CEI was documented by observing that, in the presence of CEI, the elevation of blood pressure produced by angiotensin I was significantly attenuated. The potentiating effect of CEI on the natriuretic response to ANF supports the hypothesis that converting enzyme may be involved in the metabolism of ANF.
点击下载:
PDF
(1312KB)
返 回