Continuous hepatic artery infusion of 5‐fluorouracil for metastatic colorectal cancer localised to the liver
作者:
F. M. Boyle,
R. C. Smith,
J. A. Levi,
期刊:
Australian and New Zealand Journal of Medicine
(WILEY Available online 1993)
卷期:
Volume 23,
issue 1
页码: 32-34
ISSN:0004-8291
年代: 1993
DOI:10.1111/j.1445-5994.1993.tb00534.x
出版商: Blackwell Publishing Ltd
关键词: Colorectal cancer metastases;infusional chemotherapy;Infusaid™;5‐fluorouracil
数据来源: WILEY
摘要:
Abstract:Continuous regional delivery of chemotherapeutic agents offers the prospect of maximising dose intensity at the site of localised disease, while minimising systemic toxicity. This prospective phase II study evaluates the efficacy and toxicity of hepatic arterial infusion of 5‐Fluorouracil (5‐FU) via an implantable Infusaid™ pump in previously untreated patients with localised but unresectable hepatic metastases from colorectal cancer. In 25 patients the response rate was 56% and median survival was 15 months, comparable to previous reports utilising fluorodeoxy‐uridine (FUDR). Twenty per cent of patients (all responders) survived longer than three years. Systemic toxicity was trivial, and the practice of reducing the intensity of therapy when nausea or a rise in alkaline phosphatase occurred avoided the previously described local toxicity of biliary sclerosis seen frequently with FUDR. In selected patients, particularly those with more limited disease, this form of therapy is effective and well tolerated and warrants further evaluation as an alternative to FUDR. (Aust NZ J Med 1993; 23:
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