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RACEMIZATION IN PEPTIDE SYNTHESIS

 

作者: N. LEO BENOITON,   KEIJI KURODA,   FRANCIS M.F. CHEN,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1980）
卷期: Volume 15, issue 5  

页码: 475-479

 

ISSN:0367-8377

 

年代: 1980

 

DOI:10.1111/j.1399-3011.1980.tb02924.x

 

出版商: Blackwell Publishing Ltd

 

关键词: asymmetric induction;benzoylamino acids;coupling methods;lysyl dipeptides;nuclear magnetic resonance;5(4H)‐oxazolones

 

数据来源: WILEY

 

摘要:

A laboratory experiment involving the coupling of N‐benzoylamino acids with methyl Nε‐benzyloxycarbonyl‐L‐lysinate using various methods is described. The extents of racemization are determined by analysis for the protected diastereomeric dipeptide ester products by quantitation of the separated ester methyl proton peaks of their nuclear magnetic resonance (60 MHz) spectra. Synthesis of the starting materials and additional exercises are included as

 

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