Secondary inhibition of 2‐ketoglutarate dehydrogenase complex by MPTP
作者:
Gabriella Joffe,
Janice Parks,
W Parker,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2781-2783
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: 2-Ketoglutarate dehydrogenase complex;MPP+;MPTP
数据来源: OVID
摘要:
The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria but found that this inhibition is prevented by preincubation with the radical quencher, cysteine (Cys). KDHC is also inhibited by the NO generator S-nitroso-N-acetyl-penicillamine (SNAP) and this inhibition is similarly blocked bycysteine. MPP+may inhibit KDHC secondary through a radical-mediated event rather than through directinteraction with KDHC.
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