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Direct observation of B‐form and Z‐form DNA by scanning tunneling microscopy

 

作者: Min‐Qian Li,   Jin‐de Zhu,   Jie‐Qing Zhu,   Jun Hu,   Ming‐Min Gu,   Yao‐Liang Xu,   Lan‐Ping Zhang,   Ze‐Qi Huang,   Liu‐Zhong Xu,   Xiao‐Wei Yao,  

 

期刊: Journal of Vacuum Science&Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena  （AIP Available online 1991）
卷期: Volume 9, issue 2  

页码: 1298-1303

 

ISSN:1071-1023

 

年代: 1991

 

DOI:10.1116/1.585225

 

出版商: American Vacuum Society

 

关键词: BIOPHYSICS;DNA;SCANNING TUNNELING MICROSCOPY;USES;CONFORMATIONAL CHANGES;THYMUS CELLS

 

数据来源: AIP

 

摘要:

Using a scanning tunneling microscope (STM) of atomic resolution, we have directly observed variant comformations of DNA, including normal B‐form and Z‐form DNA, with a modified working condition. STM images of natural fish sperm and calf thymus B‐form DNA and poly (dG‐me5dC) and bromized poly dCG Z‐form DNA have been obtained at a subnatural environment. These results have provided some new evidence that images characteristic of DNA molecules can be obtained with STM.

 

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