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Polymorphism Study of TcrαandγGenes in Insulin Dependent Diabetes Mellitus (Iddm) Multiplex Families

 

作者: AvoustinP.,   BriantL.,   De PrévalC.,   CambonA.,  

 

期刊: Autoimmunity  （Taylor Available online 1992）
卷期: Volume 14, issue 2  

页码: 97-100

 

ISSN:0891-6934

 

年代: 1992

 

DOI:10.3109/08916939209083126

 

出版商: Taylor&Francis

 

关键词: Insulin dependent diabetes mellitus IDDM;T-cell Receptor TCR;multiplex families;RFLP

 

数据来源: Taylor

 

摘要:

T-cell receptor (TCR)αandγgenes polymorphisms were analysed by Restriction Fragment Length Polymorphism (RFLP) in 10 Insulin Dependent Diabetes Mellitus (IDDM) multiplex families. TCRαandγalleles distribution does not significantly differ between affected and non affected children. Furthermore there was no excess of Cαor Vγallele sharing in affected sib pairs. Therefore the T-cell receptorαandγchain alleles studied do not seem to affect IDDM susceptibilityper se.

 

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