AbstractThe Great Lakes region has a wealth of natural resources, including a system of five large lakes with 20 percent of the world's surface freshwater. A century and a half of municipal, industrial, and agricultural expansion has created a variety of environmental pressures. A 1972 landmark agreement between the United States and Canada committed both countries to an ecosystem‐based approach to management and a strategy of virtually eliminating toxic chemical inputs. Over the past few decades, significant investments were made to address the region's environmental health. More recent strategies, however, were developed without adequate consideration of their economic and social impacts. Using the quality‐based framework described in Part I of this article, this case study shows that the region has moved from crisis management to a more proactive, anticipatory appro