Effect of Intravenous Omeprazole on Twenty-Four-Hour Intragastric pH in Patients with a History of Peptic Ulcer
作者:
S. Kiilerich,
L. Elsborg,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 48,
issue 2
页码: 75-80
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200676
出版商: S. Karger AG
关键词: Omeprazole;Intravenous administration;Duodenal ulcer disease;Loading dose;Dose regimens
数据来源: Karger
摘要:
To study the effect of intravenously given omeprazole on the 24-hour gastric secretion, 9 male patients with previously endoscopic proven duodenal ulcer disease were studied. Two four-dose regimens only differing in loading doses were compared. The study showed that 40 mg omeprazole, administered intravenously 4 times a day, is able to keep the gastric pH above 4 in 85% of the 24-hour study period and in 65% of the time pH was above 6. The corresponding values from the baseline period were 10 and 6%. There was no additional effect by a larger loading dose.
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