Organophosphorus compounds. II: Synthesis and cholinesterase inhibition of a series of alkyl and cycloalkyl methylphosphonofluoridothionates
作者:
H. L. Boter,
A. J. J. Ooms,
期刊:
Recueil des Travaux Chimiques des Pays‐Bas
(WILEY Available online 1966)
卷期:
Volume 85,
issue 1
页码: 21-30
ISSN:0165-0513
年代: 1966
DOI:10.1002/recl.19660850104
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
AbstractA number of alkyl and cycloalkyl methylphosphonofluoridothionates were prepared by treatment of methylphosphonothioic difluoride with a mixture of one mole equivalent each of the appropriate alcohol and triethylamine in ether or benzene medium. Reaction velocities of the irreversible inhibition of acetylcholinesterase and butyrylcholinesterase were determined and compared with those of the corresponding phosphonofluoridates. A convenient method for the preparation of methylphosphonothioic difluoride is given.
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