Ultrastructural localization of activated NF‐κB in granule cells of the rat fascia dentata
作者:
Barbara Kaltschmidt,
Thomas Deller,
Michael Frotscher,
Christian Kaltschmidt,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 4
页码: 839-844
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Electron microscopy;Laser scanning confocal microscopy;NF-κB;Synapse to nucleus signaling
数据来源: OVID
摘要:
The distribution of activated NF-κB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-κB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in proximal dendrites, somata, and nuclei but not in axon terminals of granule cells. Within the nuclei of granule cells, clusters of NF-κB immunoreactivity were detected. These data are in line with the proposed function of NF-κB as a retrograde signal transducer which transports information from synaptic sites to the nucleus to initiate gene expression.
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