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Comparison of Single-Entry and Double-Entry Two-Step Couple Screening for Cystic Fibrosis Carriers

 

作者: Leo P. ten Kate,   Joke B.G.M. Verheij,   Mark F. Wildhagen,   Henk B.M. Hilderink,   Loes Kooij,   Jan Gerben Verzijl,   Dik F. Habbema,  

 

期刊: Human Heredity  （Karger Available online 1996）
卷期: Volume 46, issue 1  

页码: 20-25

 

ISSN:0001-5652

 

年代: 1996

 

DOI:10.1159/000154320

 

出版商: S. Karger AG

 

关键词: Screening;Carriers;Cystic fibrosis;Single-entry two-step screening;Double-entry two-step screening

 

数据来源: Karger

 

摘要:

Both single-entry two-step (SETS) couple screening and double-entry two-step (DETS) couple screening have been recommended as methods to screen for cystic fibrosis gene carriers. In this paper we compare the expected results from both types of screening. In general, DETS results in a higher detection rate of couples in which both partners are carriers, but also in a higher proportion of couples with only one identified carrier who have a significant remaining risk in their offspring.

 

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