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Design of Potential Neuraminidase Inhibitors By Dehydration, Deoxygenation and Epimerization of Siastatin B

 

作者: Yoshio Nishimura,   Toshiaki Kudo,   Yoji Umezawa,   Shinichi Kondo,   Tomio Takeuchi,  

 

期刊: Natural Product Letters  （Taylor Available online 1992）
卷期: Volume 1, issue 1  

页码: 39-44

 

ISSN:1057-5634

 

年代: 1992

 

DOI:10.1080/10575639208048884

 

出版商: Taylor & Francis Group

 

关键词: 4-Ene-siastatin B;4-Deoxysiastatin B;4,5-Di-epi-siastatin B;Neuraminidase;Oxocarbenium ion of neuraminic acid

 

数据来源: Taylor

 

摘要:

Rationally designed analogs of siastatin B able to mimic oxocarbenium ion of neuraminic acid, an intermediate in the reaction catalyzed by the enzyme, were synthesized. Those types represented the improvement over siastatin B.

 

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