Chronic Inhibition of Angiotensin Converting Enzyme Decreases Ca2+‐Dependent Tone of Aorta in Hypertensive Rats
作者:
Toshio Sada,
Hiroyuki Koike,
Hiroshi Nishino,
Kiyoshi Oizumi,
期刊:
Hypertension
(OVID Available online 1989)
卷期:
Volume 13,
issue 6, Part 1
页码: 582-588
ISSN:0194-911X
年代: 1989
出版商: OVID
关键词: angiotensin converting enzyme;vascular;smooth muscle;spontaneously hypertensive rats
数据来源: OVID
摘要:
Long-term effects of a novel angiotensin converting enzyme (ACE) inhibitor, CS-622, on Ca2+-dependent tone in aortic smooth muscles of spontaneously hypertensive rats (SHR) were examined. CS-622 (3 or 10 mg/kg/day), when orally administered to SHR for 21 weeks, exhibited a dose-dependent antihypertensive action. In Krebs-Henseleit solution, removal of Ca2+caused much greater relaxation in aortas excised from control SHR than those from SHR treated with CS-622. Restoration of Ca2+from zero to 2.5 mM elicited a marked contraction in aortas from control SHR but only a small contraction in aortas from both CS-622-treated SHR and normotensive Wistar-Kyoto rats. These findings suggested that myogenic tone that resulted from increased Ca2+permeability in aortas of SHR was suppressed by long-term treatment with CS-622. The aortic tone from the individual rats correlated well with systolic blood pressure in both CS-622-treated and control SHR. The exaggerated myogenic tone in aortas of SHR was attenuated in the medium containing nicardipine but was not altered in the presence of CS-622 diacid (active form of CS-622) at a concentration high enough to fully inhibit aortic ACE. The myogenic tone in normal Ca2+concentration was not decreased in aortas excised from SHR treated with hydralazine (5 mg/kg/day) for 21 weeks. We conclude that after prolonged administration CS-622 reduced the high vascular tension resulting from increased Ca2+permeability of vascular smooth muscle membrane in SHR and that the restoration of normal Ca2+permeability of vascular smooth muscles may underlie long-term antihypertensive action of ACE inhibitors.
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