Pharmacokinetics of Intravenously Administered Nicomorphine and its Metabolites and Glucuronide Conjugates in Surgical Patients
作者:
P.M. Koopman-Kimenai,
T.B. Vree,
L.H.D.J. Booij,
R. Dirksen,
期刊:
Drug Investigation
(ADIS Available online 1994)
卷期:
Volume 7,
issue 2
页码: 63-73
ISSN:0114-2402
年代: 1994
出版商: ADIS
数据来源: ADIS
摘要:
After intravenous administration of 3,6-dinicotinoylmorphine (nicomorphine) 30, 20 and 10mg to patients undergoing surgery, this agent is rapidly metabolised into the metabolites 6-mononicotinoylmorphine (6MNM) and morphine. The elimination half-lives are 1 minute for nicomorphine, 13 minutes for 6MNM and 120 minutes for morphine. Morphine is subsequently metabolised into morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). The half-life of these 2 glucuronide conjugates is similar, about 225 minutes. A glucuronide conjugate of 6MNM was not detected. The area under the serum concentration-time curve of nicomorphine and its metabolites is linearly related to the dose.
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