Interference on the Haemostasis in Dogs with Induced Coagulopathies by Drugs Affecting the Platelet Function
作者:
Hans Johnsson,
Per Olsson,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1976)
卷期:
Volume 5,
issue 1
页码: 27-37
ISSN:1424-8832
年代: 1976
DOI:10.1159/000214116
出版商: S. Karger AG
关键词: Platelets;Acetylsalicylic acid;Dipyridamole;Phenylbutazone;Haemostasis
数据来源: Karger
摘要:
Acetylsalicylic acid and phenylbutazone increased the bleeding significantly from standardized wounds in dogs defibrinogenated with Defibrase. Administration of dipyridamole and Xylocain® had no effect. The results were the same in dogs treated with warfarin sodium. The results demonstrate the value of using laboratory animals with an induced coagulopathy when establishing the effect on the haemostasis exerted by drugs known in vitro to interfere with platelet functions. Acetylsalicylic acid and dipyridamole did not alter the activity of the K-vitamin-dependent coagulation factors, factors V, VIII, platelet count or fibrinogen concentration
点击下载:
PDF
(2487KB)
返 回