Angiotensin II Receptor Development in the Bed Nucleus of the Stria terminalis and Other Perihypothalamic Brain Regions of the Female and Male Rat
作者:
Kevin L. Grove,
Vickie I. Cook,
Robert C. Speth,
期刊:
Neuroendocrinology
(Karger Available online 1992)
卷期:
Volume 56,
issue 2
页码: 169-177
ISSN:0028-3835
年代: 1992
DOI:10.1159/000126225
出版商: S. Karger AG
关键词: Rat;Female;Bed nucleus of the stria terminalis;Suprachiasmatic nucleus;Angiotensin II receptors;Development;Ovarian hormones;Receptor autoradiography;125I sarcosine1;isoleucine8angiotensin II
数据来源: Karger
摘要:
Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII receptor binding sites and responsiveness within the POAH to microinjections of AII in the adult female rat, corresponding to the ventral portion of the bed nucleus of the stria terminalis (BSTV). To further characterize the age- and sex-dependent AII receptor binding in the BSTV and other brain regions, in vitro receptor autoradiography using 125I-sarcosine1, isoleucine8 AII (125I-SI AII) was performed on 2-, 4- and 10-week-old female and male rat brains. Rats of both sexes displayed an age-dependent increase in 125I-SI AII binding in the BSTV, as well as in the suprachiasmatic nucleus (SCh). There was no detectable difference in binding within the BSTV between the female and male of any age group. Prepubertal ovariectomy did not impair the expression of 125I-SI AII binding in the BSTV or the SCh of adult female rats. The developmental expression of AII receptors in the BSTV and SCh may therefore play a role in sexual maturation and regulation of sexual function in the rat.
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